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For example, controlled trials in diabetic polyneuropathy have employed 600 mg of ALA injected IV once daily (often given as an infusion over 30-60 minutes) for periods of 2-4 weeks, with significant efficacy observed in reducing neuropathic symptoms compared to placebo

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thus, larger and longer randomised clinical trials, such as the SURPASS-CVOT trial, are essential to fully evaluate the potential clinical advantages of dual GLP-1/GIP agonists compared with GLP-1 receptor agonists

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administered thrice daily 100 g doses of a combined GHS therapy ((GHRP)-2, GHRP-6, and sermorelin) for 134 days [16]